Rosita Missoni, who, with her husband, Ottavio Missoni, built a luxury clothing brand on a foundation of boldly colorful striped and zigzagged knitwear that helped make Milan a capital of Italian high fashion, died on Wednesday at her home in Sumirago, in Northern Italy. She was 93.

Her death was confirmed on Thursday by Angela Mariani, the communications consultant for Missoni.

What began in 1953 as a homespun venture for the Missonis was transformed in just a couple of decades into a leading fashion house with one of the world’s most recognizable brands.

If Emilio Pucci’s bold swirls helped define Italian fashion in the 1950s and ’60s, Missoni’s squiggly, striped and multicolored space-dyed designs marked the ’70s. Bernadine Morris, a fashion critic for The New York Times, called the label’s knitted garments international status symbols, writing in 1979 that the Missonis “have elevated knitted clothes to a form of art.”

At first, the Missonis sold their sweaters anonymously or under co-labels with known designers, including Emmanuelle Khanh and Christiane Bailly. Rosita eventually took over the design of the silhouettes, and Ottavio handled the patterns: space dyes, stripes, squiggles, chevrons, all in vivid colors.

Five years after the company’s founding, Missoni dresses could be purchased at La Rinascente, the upscale department store in Milan. Anna Piaggi, the editor of Vogue Italia, had Missoni designs photographed for an editorial shoot published in 1965. The family business had become a high-fashion brand.

A lyric soprano known for her clear, supple voice, Ms. Amara sang 748 performances with the Met between 1950 and 1991, an impressively long tenure.

ImageA model posing in a Missoni outfit on pillows covered in Missoni fabric.Credit...Hulton Archive/Getty Images

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